Serum fetuin-A as a perdictive biomarker of chronic kidney disease

Document Type : Original Article

Authors

1 Aswan university

2 Aswan University hospital

3 Assuit University, Faculty of Medicine

4 Student Hospital, Menofia University, Shebeen El-Kom, Menofia, Egypt.

Abstract

Background: Chronic kidney disease (CKD) is a worldwide public health problem. Fetuin A is a natural calcium antagonist. Both human and animal studies have shown that low circulating fetuin A level are associated with vascular calcification and may be an independent risk factor for premature death in CKD patients.
Objective: The aim of this study was to evaluate the effect of serum fetuin-A in the pathogenesis of chronic kidney disease and its correlation with routine renal biomarkers.
Patients and methods: The study population was divided into 3 groups. Group I: Pre-dialysis group: on conservative treatment. Group II (CKD): on regular hemodialysis, 3 sessions/week for more than 9 months. Group III (Control group).
Results: There was significant negative correlation between blood urea, serum creatinine versus serum fetuin-A in conservative group with arterial stiffness. There was significant positive correlation between eGFR and serum fetuin-A in conservative group with arterial stiffness, while there was no significant correlation between serum fetuin-A and Hb, HcT, platelets, WBCS, FBS, Na+, K+, PO4-2, serum uric acid, total bilirubin, ALT, AST, ALP, serum albumin and prothrombin time. There was significant negative correlation between serum Ca+2 and serum fetuin-A. There was significant negative correlation between total cholesterol as well as triglycerides versus serum fetuin A.
Conclusion: serum fetuin-A level significantly reduced in hemodialysis patients, significantly correlated with the disease duration, and negatively correlated with serum Ca, T. cholesterol, and T.G.

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Aswan University Medical Journal
Volume 2, Issue 2
December 2022
Pages 97-111

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