Immunohistochemical Expression of Survivin and MUC5AC in Colorectal Cancer

Document Type : Original Article

Authors

1 Department of Human Pathology , Faculty of Medicine, Aswan University

2 Department of Human Pathology , Faculty of Medicine, Sohag University

Abstract

Introduction:
Colorectal cancer (CRC) is the third most diagnosed cancer and the second leading cause of cancer-related deaths globally. Biomarkers like Survivin, an inhibitor of apoptosis protein, and MUC5AC, a mucin protein, have gained attention for their roles in cell division, apoptosis, and tumor progression. These markers may serve as potential diagnostic and prognostic tools in CRC.

Aims:
This study aimed to evaluate the expression of Survivin and MUC5AC in CRC tissues versus normal colonic mucosa and to assess their correlation with clinico-pathological features, including tumor size, grade, lymph node metastasis (LNM), tumor budding, and lymphovascular invasion (LVI). Additionally, their prognostic value in CRC patients was investigated.

Materials and Methods:
A total of 102 paraffin-embedded samples were analyzed (51 CRC, 51 normal mucosa). Immunohistochemistry (IHC) was used to detect Survivin and MUC5AC expression. An immunoreactivity score (IRS) was calculated based on staining intensity and percentage of positive cells. Data were analyzed using SPSS, with significance at p ≤ 0.05.

Results:
Survivin and MUC5AC expressions were significantly higher in CRC tissues than in normal mucosa (p < 0.001). Both biomarkers were significantly associated with LNM and LVI. Co-expression of both markers was significantly correlated (p < 0.001), while Survivin alone was associated with tumor budding.
Conclusion:
Survivin and MUC5AC are promising biomarkers for CRC diagnosis and prognosis, showing strong associations with aggressive pathological features and potential clinical utility.

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Aswan University Medical Journal
Volume 5, Issue 3
September 2025
Pages 135-147

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