Immunohistochemical Expression of GLUT-1 in Endometrial Hyperplasia and Carcinoma

Document Type : Original Article

Authors

1 Department of Pathology, faculty of medicine ,Aswan university

2 Department of Pathology, faculty of medicine ,Sohag university

Abstract

Early detection of endometrial carcinoma (EC), especially its precursor lesions, is crucial for reducing mortality but remains challenging. Immunohistochemistry (IHC), as a diagnostic or prognostic, method maybe helpful in this conflict. Glucose transporter-1 (GLUT-1) has emerged as a promising biomarker for cancer development. This study aimed to distinguish between atypical endometrial hyperplasia/ endometrioid intraepithelial neoplasia (AEH/EIN) in comparable to endometrial hyperplasia (EH) without atypia based on the percentage of stained cells and staining intensity. Additionally, the study examined the relationship between GLUT-1 expression and clinicopathological factors linked to prognosis in EC cases. Endometrial tissue was immunostained with antibody against GLUT-1. Results: A significant upward association was observed between GLUT-1 expression and disease progression from EH without atypia to EC. In EH without atypia, 33.3% of cases demonstrated weak GLUT-1 expression, whereas, among EH with atypia, 38.5% exhibited strong GLUT-1 expression, and 61.5% showed moderate expression. All cases of EC displayed strong GLUT-1 expression. GLUT-1 expression was positively correlated with increasing tumor grade and stage. Conclusions: GLUT-1 expression was increased progressively with disease progression from EH to EC and with higher grades and stages of EC.

Keywords

Main Subjects

Aswan University Medical Journal
Volume 5, Issue 2
June 2025
Pages 134-140

Files

Share

How to cite

Statistics