Validity of Platelet Mass Index in Platelet Transfusion in Management of Neonatal Thrombocytopenia

Document Type : Original Article

Authors

1 Department of Pediatrics, Faculty of Medicine , Aswan university

2 Department of Pediatrics, Faculty of Medicine , Assiut university

Abstract

ABSTRACT
Background: Platelets serve as the primary defense mechanism against hemorrhage. Neonatal thrombocytopenia is a common hemostatic abnormality among newborns in the neonatal intensive care unit (NICU), using prophylactic platelet transfusion resulted in a higher rate of death or major bleeding. Objectives: This study aimed to compare the outcome of using Platelet Mass Index (PMI) versus Platelet Count (PC) guidelines in prophylactic platelet transfusion. Methodology: This single-blinded randomized controlled trial was carried out on 140 neonates with a platelet count <100,000/ml, admitted to the NICU.
Results: A significantly higher percentage of patients needed platelets transfusion in the PC guideline group vs. the PMI guideline group (77.1% vs 17.1%). Further, there was a statistically significant higher percentage of hemorrhage, pulmonary hemorrhage and mortality in the PC group vs. the PMI group (24.3% vs 10%, p=0.025, 17.1% vs 5.7%, p=0.034v 22.9% vs 10%, p-value=0.040, respectively).
Conclusion: This study demonstrated that transfusion strategies based on PMI guidelines resulted in higher post-transfusion platelet counts compared to the PC approach. Also, significant improvements in clinical outcomes were observed in the PMI group, including lower rates of bleeding, intracranial hemorrhage, and mortality.
Keywords: NT, NICU, PMI Guideline, PC Guideline.

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Aswan University Medical Journal
Volume 5, Issue 3
September 2025
Pages 1-12

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