Background: Gouty arthritis (GA) affects joints due to the body losing its ability to metabolize uric acid. Loratadine is an antihistamine drug that shows promise as an anti-inflammatory drug. Purpose: Evaluation of the possible anti-inflammatory activity of loratadine in acute gouty arthritis in rats. Methodology: 40 rats randomly divided into 4 equal groups: Group 1 received intra-articular injection (IA) of phosphate buffer saline (PBS). Group 2 received IA of Mono urate crystals (MUC) 0.25 mg/ml. Group 3 received single dose of ibuprofen (20 mg/kg) orally 2 hours before induction of acute GA. Group 4 received a single dose of loratadine orally (10mg/ kg), 2 hours before induction of GA. Ankle diameter was assessed at 0 time, 6h, 12 h, 24 h, 48h and 72 h (after injection). Blood samples and serum were used for C- reactive protein (CRP) level assessment. Results: A significant decrease in ankle diameter in the group treated with loratadine compared to other groups. Repeated measures of ankle diameter after IA MUC; shows highly significant increase. CRP level was significantly decreased among the group treated by ibuprofen and loratadine versus MUC group. Conclusions: loratadine has a significant anti-inflammatory effect compared to ibuprofen in MUC-induced acute gouty arthritis in rats.
Hareedy, M., Abdelrahem, M., & Abo Arays, E. (2023). Evaluation of the Possible Anti-inflammatory Effects of Loratadine in Acute Gouty Arthritis in Rats. Aswan University Medical Journal, 3(2), 138-146. doi: 10.21608/aumj.2023.230906.1064
MLA
Mohammad Salem Hareedy; Mahmoud Hamdy Abdelrahem; Ebrahim Mohamed Abo Arays. "Evaluation of the Possible Anti-inflammatory Effects of Loratadine in Acute Gouty Arthritis in Rats". Aswan University Medical Journal, 3, 2, 2023, 138-146. doi: 10.21608/aumj.2023.230906.1064
HARVARD
Hareedy, M., Abdelrahem, M., Abo Arays, E. (2023). 'Evaluation of the Possible Anti-inflammatory Effects of Loratadine in Acute Gouty Arthritis in Rats', Aswan University Medical Journal, 3(2), pp. 138-146. doi: 10.21608/aumj.2023.230906.1064
VANCOUVER
Hareedy, M., Abdelrahem, M., Abo Arays, E. Evaluation of the Possible Anti-inflammatory Effects of Loratadine in Acute Gouty Arthritis in Rats. Aswan University Medical Journal, 2023; 3(2): 138-146. doi: 10.21608/aumj.2023.230906.1064