Abstract Background: Maturity-onset diabetes of the young (MODY) is a type of monogenic diabetes. MODY3 is more frequent than previously thought. Aim and objectives detect clinical characteristics of cases of MODY 3 as regarding age of disease onset, insulin dose, family history and complications in Egyptian children. Methods: This cross-sectional study was conducted on 20 cases and 10 controls. All subjects were subjected to full history taking, complete clinical examination and laboratory tests, including; C peptide assays, Glycosylated hemoglobin (HbA1c), Fasting and 2 hours postprandial blood sugar levels, Triglyceride, LDL cholesterol, Measurement of Anti-gad and anti-islets antibodies. Results: All cases (100%) had a positive family history of DM. All cases were negative for Anti-Gad and Anti-Islet. The mean age on onset of DM was 11.08 ± 2.77 years, the mean duration of DM was 2.2 ± 0.16 years. Regarding complications; 30% of cases has dental caries, 10% had neuropathy, 5% had hepatomegaly. Regarding treatment; 5% of cases were treated by oral hypoglycemic, 15 % were treated by insulin and oral hypoglycemic drugs, 15% were managed by healthy life style and 65% of cases treated by insulin with a mean dose 0.34 ± 0.19. Conclusion we suggest that a thorough clinical evaluation, including a family history, phenotypic features, a response to diabetes-specific autoantibodies, and an assessment of endogenous insulin secretion, may be a more effective first step in identifying diabetic children who require genetic testing for MODY.
Hafez, A. (2023). Clinical Characters of Egyptian children with Maturity Onset of Diabetes Type 3. Aswan University Medical Journal, 3(2), 129-137. doi: 10.21608/aumj.2023.233837.1065
MLA
Ahlam Mohamed Hafez. "Clinical Characters of Egyptian children with Maturity Onset of Diabetes Type 3". Aswan University Medical Journal, 3, 2, 2023, 129-137. doi: 10.21608/aumj.2023.233837.1065
HARVARD
Hafez, A. (2023). 'Clinical Characters of Egyptian children with Maturity Onset of Diabetes Type 3', Aswan University Medical Journal, 3(2), pp. 129-137. doi: 10.21608/aumj.2023.233837.1065
VANCOUVER
Hafez, A. Clinical Characters of Egyptian children with Maturity Onset of Diabetes Type 3. Aswan University Medical Journal, 2023; 3(2): 129-137. doi: 10.21608/aumj.2023.233837.1065